AN INNOVATION FOR SCALP HEALTH
OMA & ME Laboratories have developed a unique technology: BIOMA THERAPY™.
This approach is based on a deep understanding of the scalp and its microbiome, combined with the latest advances in dermatology, microbiology and biotechnology.
BIOMA THERAPY™ promotes a balanced scalp, optimizes cell regeneration, and stimulates deep hair growth.
Rather than just treating visible symptoms of hair problems, our innovation addresses the underlying causes of hair loss, sebum imbalance, and hair aging.
By leveraging synergies between innovative active ingredients such as Probiotics and Amino Acids, this unique technology restores the biological balance of the scalp while extending the life cycle of hair follicles.
1. Definition and composition of the scalp microbiome
Beneath the surface of our scalp, a microscopic yet essential ecosystem is at work. This scalp microbiome consists of a vast array of microorganisms: bacteria, fungi, yeasts, and other microbes coexist in a delicate balance. Far from being a simple mass of invisible cells, this microbiota plays a fundamental role in the health and appearance of our hair.
Diagramme d’un follicule pileux avec micro-organismes et tableau des tailles pour bactéries, levures et acariens.
2. The role of the microbiome in scalp health
The scalp microbiome acts as a living protective barrier, playing an essential role in the balance and health of the scalp. It consists of billions of microorganisms (bacteria, yeasts, fungi) that constantly interact with the skin and hair follicles. Its proper balance helps protect the scalp from external aggressions, maintain optimal pH, reduce dandruff, soothe irritation, and promote hair growth.
First, the microbiome forms a natural protection against external aggressions such as pollution, UV rays, and unsuitable hair products. When balanced, it prevents toxic substances and free radicals from penetrating the scalp, thereby reducing oxidative stress, which is responsible for premature aging of follicles and degradation of hair fibers. A stable microbial flora also limits the proliferation of pathogenic microorganisms like Malassezia furfur, a yeast involved in dandruff and scalp inflammation.
Role of Malassezia furfur in the pathophysiology of the cell
The scalp microbiome acts as a living protective barrier, playing an essential role in the balance and health of the scalp. It consists of billions of microorganisms (bacteria, yeasts, fungi) that constantly interact with the skin and hair follicles. Its proper balance helps protect the scalp from external aggressions, maintain optimal pH, reduce dandruff, soothe irritation, and promote hair growth.
First, the microbiome forms a natural protection against external aggressions such as pollution, UV rays, and unsuitable hair products. When balanced, it prevents toxic substances and free radicals from penetrating the scalp, thereby reducing oxidative stress, which is responsible for premature aging of follicles and degradation of hair fibers. A stable microbial flora also limits the proliferation of pathogenic microorganisms like Malassezia furfur, a yeast involved in dandruff and scalp inflammation.
Microbiome in the hair follicle of androgenetic alopecia patients
This table presents the relative abundance of major bacterial genera in the middle and lower portions of hair follicles, comparing samples from androgenetic alopecia patients to those of healthy controls.
The table highlights significant differences in follicular microbiome composition between patients and controls, notably an increase in Propionibacterium acnes in miniaturized follicles of patients. This supports the idea that microbiome imbalances can influence scalp health and hair growth.
Finally, the microbiome also acts on hair growth by influencing the hair follicle cycle. Research has shown that certain bacteria in the microbiome produce antimicrobial peptides and bioactive metabolites, promoting vascularization of the hair follicle and thus stimulating the growth phase (anagen). By reducing chronic inflammation often associated with hair loss, it allows follicles to function longer and more effectively. An alteration of the microbiome can, on the other hand, disrupt the hair cycle by accelerating the transition to the telogen phase (hair loss), which results in progressive thinning of the hair. Finally, the microbiome plays a key role in regulating dandruff and irritation.
3. Evolution of the scalp microbiome with age, environment, and care: a constantly adapting flora
The scalp microbiome, like that of the skin, is a dynamic ecosystem that evolves under the influence of biological and environmental factors. From birth, the microbial composition of the scalp is influenced by genetic heritage, mode of delivery, and early interactions with the environment. However, over the years, this protective flora transforms, adapting to hormonal changes, hair care habits, and external aggressions.
With aging, the scalp microbiome undergoes progressive changes that can impact hair and scalp health. Several phenomena are observed: a decrease in bacterial diversity, where certain beneficial strains, such as Staphylococcus epidermidis, see their presence reduced, leaving more room for opportunistic microorganisms; a deregulation of sebum production, where a balanced microbiome helps maintain adequate sebum production in young adults, but with age, sebum secretion tends to decrease, making the scalp drier and more sensitive. In some people, conversely, excess sebum can occur, promoting the proliferation of Malassezia and the appearance of dandruff.
Hair hygiene must also be adapted to avoid imbalances. Too frequent washing can eliminate protective bacteria and weaken the scalp's flora. Conversely, lack of hygiene can promote the accumulation of sebum and residue, creating an environment conducive to the proliferation of opportunistic yeasts like Malassezia furfur, responsible for dandruff and itching. The ideal frequency of washing depends on hair type and lifestyle, but generally, 2 to 3 washes per week with a gentle shampoo are sufficient to maintain a healthy balance.
4. Principles for preserving scalp microbiome balance
The scalp microbiome is a fragile ecosystem that plays an essential role in scalp health and hair vitality. Preserving its balance requires a holistic approach, combining appropriate care, balanced hygiene, and beneficial nutrition for the microbial flora. By adopting the right practices and avoiding unnecessary aggressions, it is possible to maintain a resilient scalp microbiome, thus promoting a healthy scalp and strong hair.
In parallel, it is important to respect the physiological pH of the scalp, which is between 4.5 and 5.5. A pH that is too alkaline can disrupt the microbial flora and promote irritation or dandruff. The use of pH-neutral or slightly acidic care helps maintain a balanced and functional microbiome. Certain active ingredients, such as prebiotics and probiotics, can be integrated into hair care to support bacterial diversity and strengthen the protective barrier of the scalp.
The use of targeted active ingredients in hair care can also help restore and stabilize the scalp microbiome. Ingredients such as melatonin have shown beneficial effects on regulating biological processes of the scalp, reducing oxidative stress, and promoting the anagen phase (hair growth). Certain essential amino acids (arginine, cysteine, methionine) also strengthen the hair fiber and optimize the metabolism of hair follicles.
Probiotics in the scalp microbiome are major allies for scalp health. When combined with amino acids, they create an optimal environment, strengthening natural defenses and promoting a balanced microbiome. This synergy helps protect the scalp, regulate pH, limit inflammation, and support the growth of beneficial microorganisms.
1. Strengthening and protecting the scalp skin barrier
Probiotics and amino acids work in a complementary way to strengthen the skin barrier of the scalp. Probiotics help stabilize the microbial ecosystem and maintain a protective layer, while amino acids such as cysteine, methionine, and arginine participate in the synthesis of ceramides and other essential structural lipids. This increased production of ceramides limits water loss, improves scalp hydration, and reduces its permeability to external aggressions such as pollution or aggressive hair products. Consequently, the scalp becomes less prone to irritation and redness, and hair benefits from better follicular anchoring.
Additionally, cysteine is involved in the production of glutathione, a major antioxidant that protects membrane lipids from peroxidation, thus preserving the integrity of the skin barrier
This diagram illustrates the interactions between intracellular cysteine, glutathione homeostasis, and other metabolic pathways leading to peroxidation.
Arginine is also involved in various metabolic pathways, including the production of nitric oxide, which can influence the proliferation and differentiation of keratinocytes, cells essential for the formation of the skin barrier. Although the direct link between arginine and ceramide synthesis is less documented, its role in skin metabolism suggests an indirect contribution to the health of the lipid barrier
2. pH balance and inflammation reduction
The pH of the scalp is a key element in maintaining its balance and health. An optimal pH, between 4.5 and 5.5, promotes a stable environment for the scalp microbiome, thus limiting the proliferation of pathogenic microorganisms. Among them, Malassezia, a yeast naturally present on the skin, can become invasive if the balance is disrupted, leading to itching, dandruff, and chronic inflammation.
The association of probiotics and amino acids plays a fundamental role in pH regulation and inflammation reduction. Probiotics help stabilize the microbial flora by producing organic acids that maintain optimal acidity, thus preventing pathogenic microorganisms from proliferating. On their side, amino acids such as glutamine and arginine participate in regulating cellular metabolism, reducing the production of pro-inflammatory cytokines responsible for scalp irritation.
Moreover, a pH imbalance can also alter sebum production, which aggravates inflammation and weakens the skin barrier. By restoring a stable pH and healthy microbiome, this synergy helps reduce redness, soothe itching, and prevent persistent dandruff conditions.
The impact of unbalanced pH on sebum production and skin barrier integrity
This diagram illustrates how a dysfunction of the skin barrier can lead to inflammation and itching, highlighting the importance of maintaining a balanced pH to preserve scalp health.
3. Stimulating beneficial microflora
The scalp microbiome is composed of a multitude of microorganisms that coexist in balance. When this balance is disrupted by factors such as stress, pollution, or the use of aggressive hair products, the proliferation of opportunistic bacteria and yeasts (Malassezia, Staphylococcus aureus) can lead to inflammation, dandruff, and a sensitized scalp.
Probiotics play a key role in regulating the microflora, producing natural antimicrobial peptides that inhibit pathogen development and strengthen beneficial bacterial diversity. On their side, certain amino acids, such as glutamine and serine, serve as energy substrates for beneficial bacteria, promoting their growth and stability within the skin microbiome.
Figure: the metabolic pathways of amino acids
The diagram presents an overview of amino acid metabolic pathways, showing how compounds such as glutamine and serine are absorbed by microbiome bacteria.
Amino acids such as glutamine and serine play a crucial role as energy substrates for beneficial bacteria, thus promoting their growth and stability within the skin microbiome. Glutamine is a non-essential amino acid abundant in the body. It is used by cells for the synthesis of nucleotides, nicotinamide adenine dinucleotide phosphate (NADPH), antioxidants, and other biosynthetic pathways essential for maintaining cellular integrity and function.
Serine, on the other hand, is involved in the synthesis of proteins, phospholipids, and nucleotides. It also serves as a precursor for the production of glycine and cysteine, two amino acids important for various metabolic functions.
These amino acids are absorbed by bacterial cells via specific transporters and integrated into various metabolic pathways to provide the energy necessary for their growth and microbiome stability
The innovation of BIOMA THERAPY™ is not limited to balancing the microbiome through probiotics. The integration of innovative active ingredients such as melatonin brings a new dimension to scalp health and hair fortification. By acting on growth, hair structure, and scalp environment, this synergy helps strengthen hair at the source while ensuring an environment conducive to their development.
1. Melatonin: A growth and protection booster
Melatonin and amino acids do not just act in isolation; their interaction maximizes their respective effects. Melatonin protects, stimulates, and strengthens, while amino acids nourish and balance. This synergistic approach results in visibly stronger, better-anchored hair that is less susceptible to external aggressions.
Melatonin, often associated with sleep, plays a much broader role in our body, including at the hair level. It plays a key role in hair protection and regeneration by acting directly on hair follicles and the scalp. By prolonging the anagen phase of the hair cycle, it stimulates hair growth and slows premature hair loss.
Fig.1
Mean serum concentration after two-week treatment with the cosmetic melatonin solution
Fig.2
Objective and subjective assessment of the severity of alopecia
Thanks to its powerful antioxidant properties, it neutralizes free radicals responsible for follicular aging and oxidative stress, thus preserving hair vitality. Additionally, it helps regulate inflammation of the scalp, a key factor in microbiome imbalances and hair problems such as dandruff and irritation. By stabilizing the scalp environment, melatonin promotes a balanced microbiome, essential for stronger and healthier hair.
2. A triple synergy: Probiotics + Melatonin + Amino Acids
The combination of probiotics, melatonin, and amino acids represents a holistic and innovative approach to hair health. Each of these elements acts at a specific level to optimize growth, resistance, and scalp balance.
Probiotics stabilize the microbiome, regulate bacterial flora, and prevent the proliferation of pathogenic microorganisms, thereby reducing inflammation and scalp imbalances.
Melatonin, for its part, plays an essential role in stimulating hair follicles, prolonging the anagen phase and protecting hair against oxidative stress and external aggressions. Thanks to its powerful antioxidant properties, it neutralizes free radicals responsible for premature aging of follicles, thereby reducing their weakening and hair miniaturization.
Stimulation of anti-oxidant enzyme production by Melatonin
Moreover, melatonin stimulates blood microcirculation in the scalp, optimizing the supply of nutrients and oxygen to hair cells. Finally, it helps regulate inflammation of the scalp, a key factor in hair disorders such as dandruff, dryness, or hyperseborrhea, thus promoting a healthy environment conducive to hair growth.
Finally, amino acids provide the fundamental building blocks of keratin, strengthening hair structure and promoting more robust and durable growth. This synergy acts on three complementary axes: it balances and protects the scalp, improves vascularization and nutrient supply, and strengthens the hair fiber while stimulating its regeneration. Together, these three elements form an advanced strategy for stronger, denser hair better protected against daily aggressions.
1. A rigorous selection of active ingredients
The choice of active ingredients is based on a rigorous scientific approach, guaranteeing their effectiveness on the scalp and hair. Each active ingredient is selected based on clinical studies demonstrating its beneficial action on hair fiber fortification, microbiome regulation, and protection against external aggressions. This selection is not limited to raw effectiveness: it also takes into account compatibility with the scalp ecosystem, in order to avoid any imbalance of the skin microbiome, a key factor in hair health.
By integrating ingredients such as melatonin, essential amino acids, and specific probiotics, this formula acts on multiple levels simultaneously: stimulation of hair growth, strengthening of the skin barrier, and improvement of hair resistance to external aggressions (pollution, oxidative stress, aggressive products). Each active ingredient is thus chosen for its ability to interact synergistically with other components, thereby maximizing benefits for the scalp and hair.
2. Optimal concentration for healthy scalp
The effectiveness of a hair care product depends as much on the quality of active ingredients as on their precise dosage. Too low a concentration would risk producing no tangible effect, while excessive dosage could disrupt the scalp microbiome balance, cause irritation, or weigh down the hair fiber. The challenge is therefore to find the right balance: an optimal concentration, allowing visible and lasting results to be achieved, without compromising scalp health.
This approach is based on a formulation based on scientific tests, where each ingredient is dosed to offer proven effectiveness, while respecting the physiological needs of the scalp. For example, melatonin is dosed to prolong the anagen phase without overstimulation, while amino acids are present in ideal quantities to strengthen keratin without a weighing effect. Similarly, probiotics are integrated in a concentration that promotes a balanced microbiome, thus avoiding the appearance of irritation or seborrheic imbalances.
The objective is to offer a treatment that acts in depth while remaining gentle and respectful of the skin ecosystem, thus guaranteeing lasting improvement in hair and scalp health.
1. Proven results: clinical tests and consumer feedback
Our products are not just marketing promises. They undergo rigorous clinical testing to measure their effectiveness on several essential parameters:
Increase in the anagen phase, the active hair growth phase.
Significant reduction in hair loss after three months of regular use.
Reduction of dandruff and irritation, for a soothed and healthy scalp.
Consumer feedback confirms these observations: they report denser, more resistant hair and better scalp comfort. This scientific and user validation reinforces our commitment to effective and respectful hair care.
2. Transparency and scientific commitment
Innovation and transparency are at the heart of our approach. We commit to:
Publishing clinical studies on which our formulas are based.
Providing complete traceability of ingredients, from their origin to their mode of action.
Avoiding exaggerated claims, by clearly explaining the expected effects of each product.
This transparency allows our users to understand precisely how our treatments act on their scalp and hair, thereby strengthening confidence in our products.
3. Manufacturing according to the strictest standards
Our products are designed according to high quality and safety standards, in order to guarantee safe and effective use:
Compliance with European and international regulations: Our formulas comply with the strictest cosmetic standards.
Dermatological tests: Each product is evaluated to guarantee optimal tolerance.
Certified laboratory production: Our factories comply with Good Manufacturing Practices (GMP), guaranteeing optimal stability and effectiveness.
From ingredient selection to market launch, each step is supervised by rigorous controls to ensure the quality and safety of our products.
4. Freshness, stability, and respect for the microbiome
Product stability is essential to preserve their effectiveness throughout their use. Our formulas are developed to guarantee optimal preservation of active ingredients without adding superfluous preservatives or agents that disrupt the scalp.
This approach ensures high-performance treatments adapted to prolonged use, respecting the balance of the scalp microbiome and guaranteeing consistent and reproducible results.
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OMA & ME Laboratories have developed a unique technology: BIOMA THERAPY™.
This approach is based on a deep understanding of the scalp and its microbiome, combined with the latest advances in dermatology, microbiology and biotechnology.
BIOMA THERAPY™ promotes a balanced scalp, optimizes cell regeneration, and stimulates deep hair growth.
Rather than just treating visible symptoms of hair problems, our innovation addresses the underlying causes of hair loss, sebum imbalance, and hair aging.
By leveraging synergies between innovative active ingredients such as Probiotics and Amino Acids, this unique technology restores the biological balance of the scalp while extending the life cycle of hair follicles.
I. SCALP MICROBIOME: ESSENTIAL ROLE
1. Definition and composition of the scalp microbiome
2. The role of the microbiome in scalp health
3. Evolution of the scalp microbiome with age, environment, and care
4. Principles for preserving scalp microbiome balance
II. AMINO ACIDS AND THEIR SYNERGY WITH THE MICROBIOME
1. Strengthening and protecting the scalp skin barrier
2. pH balance and inflammation reduction
3. Stimulating beneficial microflora
III. COMBINING MELATONIN AND AMINO ACIDS
1. Melatonin: A growth and protection booster
2. A triple synergy: Probiotics + Melatonin + Amino Acids
IV. A FORMULATION THAT RESPECTS AND STRENGTHENS THE MICROBIOME
1. A rigorous selection of active ingredients
2. Optimal concentration for healthy scalp
V. SCIENTIFIC COMMITMENT AND QUALITY
1. Proven results: clinical tests and consumer feedback
2. Transparency and scientific commitment
3. Manufacturing according to the strictest standards
4. Freshness, stability, and respect for the microbiome
